The Rocket required no time at all to dispatch world No.17 Lisowski at the Alexandra Palace, wrapping up victory with a comfortable 6-1 scoreline.
O'Sullivan, looking for an incredible eighth Masters title, took the first frame before Lisowski produced a break of 104 to level things up at 1-1.
But it was all O'Sullivan from there on in, with the six-time world champion reeling off five frames without reply to book a date with Neil Roberson in the next round.
After the match, the Rocket appeared in a relaxed mood as he reminded his rivals of his status as one of the greatest players to ever rock up on the old green baize.
"I just savour every match I play", he told Eurosport. "20 majors, most successful player of all-time. I've just got to keep thinking of that and take that into the match and let him [Neil Robertson] worry about him."
Snooker fans on social media loved O'Sullivan's confidence and predicted that his remaining rivals might now be running scared.
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One person said: "Ronnie O’Sullivan coming out punching in these interviews. Normally very self critical and plays down his performance. Today he’s come out fighting, acknowledging he’s the best player ever and saying others must catch up to him. So refreshing…dangerous animal now #SnookerMasters."
Someone else added: "That interview was outstanding. Ronnie when he isnt thinking about winning or his game is a dangerous beast. He is in fine form in life!!"
A third user commented: "Quality interview with Ronnie after the match. Refreshing to hear someone who is as great as he is not role out cliche after cliche."
And another fan chimed in with: "Yesss love that bit of arrogance by Ronnie O’Sullivan in the interviews there. Needs to bring that out more. Dangerous man this week #themasters."
O'Sullivan will meet Robertson in the quarter-finals on Thursday.